PT-141 (Bremelanotide) – Actions & Benefits

PT-141 (Bremelanotide) is a synthetic peptide originally developed from Melanotan II. It primarily enhances sexual arousal and performance by stimulating the central nervous system, rather than affecting hormone levels like testosterone or estrogen.

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Actions of PT-141

1. Stimulates the Melanocortin System – PT-141 binds to melanocortin receptors (MC3R & MC4R) in the brain, which are linked to sexual function and arousal.
2. Enhances Sexual Desire & Performance – Unlike PDE5 inhibitors (Viagra, Cialis), PT-141 works directly on the brain, increasing libido in both men and women.
3. Treats Sexual Dysfunction – Approved by the FDA for hypoactive sexual desire disorder (HSDD) in women and used off-label for erectile dysfunction (ED) in men.
4. Increases Blood Flow – Can improve circulation, which supports better erections and heightened sensitivity.
5. May Affect Mood & Energy – Some users report enhanced mood, confidence, and overall well-being due to its action on the nervous system.

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Benefits of PT-141

✅ Boosts Libido in Men & Women – Works even when other treatments (like testosterone or PDE5 inhibitors) fail.
✅ Treats Erectile Dysfunction (ED) & HSDD – Helps men achieve and maintain erections while increasing sexual desire in women.
✅ Works Independently of Hormones – Unlike testosterone or estrogen therapy, PT-141 enhances arousal without altering hormone levels.
✅ Fast-Acting & Long-Lasting Effects – Effects can last 6-12 hours, with some reports of residual benefits for up to 72 hours.
✅ Potential Mood & Energy Boost – Some users experience mild euphoria, increased motivation, and reduced anxiety.